Analysis of the characteristics
Upload time：2017-02-23 Browse：
Author: Wang Ying Chen Na Zhang Lei Yang Shuo pan Fan Jian Hua
Abstract: Objective To study the characteristics of tremor in patients with Parkinson's disease (PD) in different clinical stages. Methods 2014-11 - 75 patients with PD diagnosed in Beijing Tiantan Hospital affiliated to Capital Medical University were selected for clinical diagnosis of 2015-05. Patients with at least one extremity or static postural tremor, according to the Hoehn-Yahr stage is divided into 1~1.5 stage, 2~2.5 stage and 3 stage 3 groups were detected with static posture and holding 1000 advantages of frequency, amplitude and G tremor tremor rhythm form. Results (1) the dominant frequency of tremor was 4~7 Hz under static state and posture state, and there was no significant difference between 1~1.5 and 2~2.5 and phase 3 (P>0.05). Under the condition of 1000 g, the 1~1.5 phase was significantly different between the 2~2.5 and the phase (P<0.01), and the dominant frequency of patients with 1~1.5 in addition to 4~7 Hz, but also 7~10 Hz, irregular and no tremor. (2) tremor amplitude: with the progress of the disease has a downward trend. (3) the form of tremor rhythm: the rhythm of tremor in different clinical stages of patients with rest, posture and holding of G was mainly in the form of alternating, but with the progress of the disease, the ratio of non alternating rhythm increased with the trend of the disease in 1000 cases. Conclusion the tremor of patients with PD belongs to central tremor. The dominant frequency of rest and postural tremor is 4~7HZ, which does not change with the progression of the disease. In the early stage of the disease, the dominant frequency of tremor in the 1000 g state may be affected by the peripheral regulation. Tremor rhythm was not affected by disease progression and posture. With the development of the disease, the ratio of non alternating rhythm increased, and the amplitude of tremor decreased.
Key words: Parkinson's disease; Hoehn-Yahr staging; tremor; dominant frequency
CLC number: R742.5 document code: A article number: 1006-2963 (2017)
Analysis of tremor characteristics in patients with Parkinson's disease in different stages WANG Ying*, PAN Hua, JIAN Fan, CHEN Na, ZHANG Lei, YANG Shuo. *Department of Neurology, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing100050, China
Corresponding author:WANG Ying, Email:firstname.lastname@example.org
ABSTRACT:Objective To explore the characteristics of the tremor of Parkinson's disease (PD), including tremor frequency, amplitude and rhythm form in PD patients with different clinical stages. Methods From November 2014 to May 2015, 75 patients who were definitely or probably diagnosed as PD in a neurological ward were tested and analyzed for dominant tremor frequency, amplitude and rhythm under resting-state, posturing and holding 1000g state respectively. Candidates with stationary or postural tremor in at least one upper extremity, were divided into 1-1.5 phase, 2-2.5 phase, and phase groups according to the Hoehn-Yahr 3 stage. Results (1) The predominant frequency of tremor: the predominant frequency of tremor was 4-7 Hz in rest and Postural positions. There was no significant difference among different clinical stages (P>0.05). When holding 1000 g load, there was a statistically significant difference between the 1-1.5 phase and 2-2.5, 3 phases (P<0.01). Patients in 1-1.5 phase had tremor frequency of 4-7 Hz, 7-10 Hz, or irregular tremor and no tremor occurs. (2) Tremor amplitude: It was observed that the amplitude of tremor decreased with the progression of the disease. rhythm pattern: rhythm pattern 3 Tremor of tremor at different status in different clinical stages was alternating rhythm tremor, but with the progress of the disease, the proportion of non alternating rhythm had increased. Conclusions Tremor of PD was central tremor. Dominant frequency of rest and Posture tremor was 4-7 Hz, and did not change with the progression of the disease. At the early stage of PD, dominant tremor frequency when holding load may be subject 1000 g to peripheral regulation and varied. Tremor rhythm is not affected by disease progression and posture. But with the disease progression, the proportion of non-alternating rhythm increases, tremor amplitude decreases.
Key words: Parkinson's disease; Hoehn-Yahr stage; tremor; dominant frequency
Parkinson's disease (Parkinson disease, PD) is a high incidence of motor disorders, almost all patients will be at a specific time in the process of disease tremor. The clinical manifestations of PD may be different, some patients in the early stage of the disease showed tremor, may eventually disappear, while some patients will be sustained by tremor [1-3]. PD patients mainly manifested as static tremor, in addition to the performance of tremor [4-5]. At present, there is no domestic and foreign research on the characteristics and specificity of tremor in patients with different stages of PD according to Hoehn-Yahr. In this study, we recorded the dominant frequency, amplitude and rhythm of tremor in patients with different clinical stages of PD by electromyography. The purpose of this study was to investigate the specificity of tremor with PD disease progression.
1 objects and methods
75 PD 1.1 2014-11 - 2015-05 patients collected in Beijing Tiantan Hospital affiliated to Capital Medical University from patients, male 37 cases, female 38 cases, age 35~86 years old, the average (61 + 11) years; the duration of 8 months ~12 years, the average (4.4 + 2.7) years. Diagnostic criteria refer to the 2006 Chinese Medical Association neurology branch of the movement disorders and PD group proposed "China PD diagnostic criteria" and the International Association for the advancement of movement disorders (MDS) revised version of the latest PD